Developing Genetic Maps
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چکیده
We can determine θs for pairs of genes or loci. Next question is how to place them in a genetic map; i.e., grouping loci into linkage groups and ordering sets of 3 or more loci. 1. Grouping loci into linkage groups The question beyond determining linkage of any two loci is the ordering of the loci into a reasonable genetic map. Ordering can be done using the MLE of θ, determined via a two-point evaluation described before, in conjunction with the lod score (Z) or the probability value of linkage. Commonly used criteria, e.g., in the computer program MAPMAKER (Lander et al., 1987), are as follows:
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